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POSTDOCTORAL POSITION (INSERM, RENNES): Deciphering the crosstalk between human macrophages and Tfh cells in steady- state and in B cell lymphomas.
Publicació: 17/12/2019
Referència: 9543
Descripció:

 

A 2 years post-doctoral position is available at the INSERM UMR1236 headed by the Pr
Karin TARTE (Rennes, France, https://micmac.univ-rennes1.fr/en) to work within the frame
of B-cell lymphoma physiopathology.
The research project of the unit is divided in two axes: i) study of normal B cell
differentiation and deregulation of these mechanisms during lymphomagenesis, ii) study of
lymph node microenvironment and in particular lymphoid stromal cells, myeloid cells, and
follicular helper T-cells and their deregulation during lymphomagenesis. Successful
applicant will join our multidisciplinary team located within the Health Campus in Rennes
(https://www.tourisme-rennes.com/en). In this environment he/she will access to state-of-
the-art facilities (10X Genomics & C1_Biomark, Flow cytometry/Cell-sorting/CYTOF,
microscopy platform...) for conducting this research project and to our unique lymphoma
tissue bank including frozen viable samples suitable for functional analysis.
The proposed project aims to characterize the crosstalk between human
macrophages and Tfh cells in steady-state and in B cell lymphomas. T follicular
helper (Tfh) cells are essential for efficient humoral responses. We hypothesize that
macrophages (Mac) play a major role in the induction of Tfh cells in human lymphoid
organs and that an altered Mac/Tfh dialogue is involved in the pathogenesis of FL, a
disease strongly dependent on a specific tumor-supportive niche. We plan to combine
unbiased methods for single-cell analysis (scRNA-seq, CyTOF, high dimensional imaging
[Hyperion]), functional assays using cells directly purified from human samples (non-
pathological and B cell lymphomas) and relevant in vitro culture models. This project will
provide novel insight into the role of macrophages in the induction of normal humoral
responses in human.
The applicant should be a highly motivated scientist with a solid background in
immunology. Skills in large-scale RNAseq approaches, flow cytometry/CyTOF, and tissue
imaging would be appreciated but each of them is not strictly required. The project will
involve close cooperation with other biologists and bioinformaticians. The lab is operating
in French and English. The position should start early 2020.
Interested applicants should submit a CV and list of publications, a statement of research
interests, and the names of two referees with contact information to Dr Mikael Roussel
([email protected]) and Pr Karin Tarte ([email protected]).

A 2 years post-doctoral position is available at the INSERM UMR1236 headed by the PrKarin TARTE (Rennes, France, https://micmac.univ-rennes1.fr/en) to work within the frameof B-cell lymphoma physiopathology.

The research project of the unit is divided in two axes:

i) study of normal B celldifferentiation and deregulation of these mechanisms during lymphomagenesis

ii) study oflymph node microenvironment and in particular lymphoid stromal cells, myeloid cells, andfollicular helper T-cells and their deregulation during lymphomagenesis.

Successful applicant will join our multidisciplinary team located within the Health Campus in Rennes (https://www.tourisme-rennes.com/en).

In this environment he/she will access to state-of-the-art facilities (10X Genomics & C1_Biomark, Flow cytometry/Cell-sorting/CYTOF, microscopy platform...) for conducting this research project and to our unique lymphomatissue bank including frozen viable samples suitable for functional analysis.

The proposed project aims to characterize the crosstalk between humanmacrophages and Tfh cells in steady-state and in B cell lymphomas. T follicular helper (Tfh) cells are essential for efficient humoral responses. We hypothesize thatmacrophages (Mac) play a major role in the induction of Tfh cells in human lymphoidorgans and that an altered Mac/Tfh dialogue is involved in the pathogenesis of FL, adisease strongly dependent on a specific tumor-supportive niche. We plan to combineunbiased methods for single-cell analysis (scRNA-seq, CyTOF, high dimensional imaging [Hyperion]), functional assays using cells directly purified from human samples (non-pathological and B cell lymphomas) and relevant in vitro culture models.

This project will provide novel insight into the role of macrophages in the induction of normal humoralresponses in human.The applicant should be a highly motivated scientist with a solid background inimmunology. Skills in large-scale RNAseq approaches, flow cytometry/CyTOF, and tissueimaging would be appreciated but each of them is not strictly required. The project will involve close cooperation with other biologists and bioinformaticians. The lab is operating in French and English. The position should start early 2020.

Interested applicants should submit a CV and list of publications, a statement of researchinterests, and the names of two referees with contact information to Dr Mikael Roussel([email protected]) and Pr Karin Tarte ([email protected]).